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目的 评价拉司太特胶囊单药的临床疗效并观察临床应用中的毒副作用。方法 采用拉司太特单药治疗晚期恶性肿瘤 2 3例 ,可评价 2 0例。结果 总有效率 3 5 .0 0 % ,对小细胞肺癌为 5 5 .60 % ( 5 /9) ,对非小细胞肺癌为 16.67%( 1/6) ,对胃癌为 2 5 % ( 1/4)。剂量限制毒性为骨髓抑制 ,有轻度消化道反应 ,对肝肾功能无明显影响。结论 拉司太特单药治疗晚期肿瘤有一定疗效 ,毒副反应可以耐受。
Objective To evaluate the clinical efficacy of Losartrate capsules and to observe the side effects in clinical application. Methods Salbutamol monotherapy in the treatment of advanced malignant tumors in 23 cases, 20 cases can be evaluated. Results The total effective rate was 35.0%, that of small cell lung cancer was 55.60% (5/9), that of non - small cell lung cancer was 16.67% (1/6), and that of gastric cancer was 25% (1 / 4). Dose-limiting toxicity for bone marrow suppression, mild digestive tract reaction, no significant effect on liver and kidney function. Conclusions Lasoside monotherapy has some curative effect on advanced tumors, and toxicity can be tolerated.