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系统性红斑狼疮(systemic lupus erythematosus,SLE)发病机制复杂,在遗传易感性上涉及多种基因[1]。有研究[2]表明造血细胞特异性Lyn底物1(HS1)是一种重要的B淋巴细胞受体(BCR)介导的信号转导分子。HS1基因EPEP366-367插入多态与SLE发病有关[3]。作者运用RT-PCR/单链构象多态性
The pathogenesis of systemic lupus erythematosus (SLE) is complex and involves a variety of genes in genetic susceptibility [1]. Some studies [2] showed that hematopoietic-specific Lyn substrate 1 (HS1) is an important BCR-mediated signal transduction molecule. HS1 gene EPEP366-367 insertion polymorphism and SLE pathogenesis [3]. The authors used RT-PCR / single-strand conformation polymorphism