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5. Screening and identification of human ZnT8-specific single-chain variable fragment （scFv） from type

Screening and identification of human ZnT8-specific single-chain variable fragment （scFv） from type

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：cys_1688

【摘 要】

：

Zinc transporter 8(ZnT8) is a major autoantigen and a predictive marker in type 1 diabetes(T1D). To investigate ZnT8-specific antibodies, a phage display librar

【作 者】

：

Qian Wu Xiaodong Wang Yong Gu 

【机 构】

：

DepartmentofEndocrinology,KeyLaboratoryofAntibodyTechnique

【出 处】

：

中国科学：生命科学英文版

【发表日期】

：

2016年7期

【关键词】

：

噬菌体展示 单链抗体 SCFV 糖尿病 可变区 筛选 人类 特异性抗体 Zinc transporter 8 （ZnT8）  phage display  si 

【基金项目】

：

Acknowledgements This work has been supported by National Natural Science Foundation of China （81070622, 81370939）, Provincial Six Talent Foundation of Jiangsu （2010-022）, Municipal Science and Techno

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Zinc transporter 8(ZnT8) is a major autoantigen and a predictive marker in type 1 diabetes(T1D). To investigate ZnT8-specific antibodies, a phage display library from T1 D was constructed and single-chain antibodies against ZnT 8 were screened and identif

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