雌性生殖干细胞的发现打破了传统的“固定卵泡理论”。研究表明,在人和小鼠卵巢中,该类细胞定位于卵巢表面上皮,并可在其中检测到Oct4、Sox-2、Nanog、Vasa等生殖细胞和干细胞特异性标志物的存在;且2条重要的信号途径——Notch和Hippo在雌性生殖干细胞增殖与分化的过程中发挥重要的作用。 The discovery of female reproductive stem cells broke the traditional “fixed follicle theory.” Studies have shown that in human and mouse ovary, these cells located in the ovarian surface epithelium, and can be detected in which Oct4, Sox-2, Nanog, Vasa and other germ cells and stem cell-specific markers exist; and 2 Important signaling pathways - Notch and Hippo play an important role in the proliferation and differentiation of female germline stem cells.