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目的:观察冠心病介入术患者的病变血管情况与中医证候分布的关系。方法:对924例冠心病介入术患者的病变血管数目、狭窄程度及中医证候学数据进行前瞻性及回顾性调查。结果:(1)与病变血管数目的相关性:标实证和本虚证与病变血管数目有正相关关系。标实证中,心血瘀滞、气机郁滞、阴寒凝滞与病变血管数目均呈正相关,其中相关性最强的是心血瘀滞证。本虚证中,阳虚和肝肾阴虚与病变血管数目有正相关关系,相关性最强的是阳虚证。9项兼证均与病变血管数目有正相关关系,阳虚合并阴寒凝滞及心血瘀滞与病变血管数目的相关性最强。(2)与病变血管狭窄程度的相关性:未发现与左主干(LMCA)狭窄程度有正相关关系的中医证候。标实证与左前降支(LAD)狭窄程度有正相关关系,其中心血瘀滞与LAD狭窄程度有正相关关系。本虚证与LAD狭窄程度无相关关系。兼证中,心阳虚合并心血瘀滞与LAD狭窄程度有正相关关系。心阳虚与左回旋支(LCX)狭窄程度有正相关关系。其余证候与LCX狭窄程度无正相关关系。标实证与右冠状动脉(RA)狭窄程度有正相关关系,其中心血瘀滞、痰浊壅滞、气机郁滞与RA狭窄程度均有正相关关系,其中心血瘀滞与RA狭窄程度的相关性最强。本虚证与RA狭窄程度无相关关系。兼证中,阳虚合并心血瘀滞、心阳虚合并心血瘀滞、心气虚合并心阳虚及心血瘀滞、阳虚合并阴寒凝滞及心血瘀滞与RA狭窄程度均有正相关关系。结论:阳虚血瘀证与冠心病介入术患者的病变血管数目、病变血管狭窄程度均有正相关关系,且相关性强、相关系数较大,验证了颜德馨教授关于“阳虚血瘀乃冠心病介入术后再狭窄的基本病机”这一假说的正确性。
Objective: To observe the relationship between the pathological changes of blood vessels and the distribution of TCM syndromes in patients with coronary artery disease. Methods: A prospective and retrospective investigation was made on the number of vascular lesions, the degree of stenosis and the TCM syndrome data of 924 patients undergoing coronary intervention. Results: (1) Correlation with the number of vascular lesion: There is a positive correlation between the standard evidence and Benxu syndrome and the number of vascular lesions. Standard evidence, the blood stasis, qi stagnation, cold coagulation and vascular lesions were positively correlated, of which the strongest correlation is the blood stasis card. Deficiency syndrome, yang and liver and kidney disease and vascular lesions have a positive correlation between the number of the most relevant is yang deficiency syndrome. There were positive correlations between the nine syndromes and the number of vascular lesions. The correlation between yin deficiency and cold coagulation and blood stasis was the strongest. (2) Correlation with the degree of vascular stenosis: No TCM syndromes were found that had a positive correlation with the degree of stenosis of left main trunk (LMCA). There is a positive correlation between standard evidence and the degree of stenosis of left anterior descending artery (LAD), and there is a positive correlation between blood stasis and the degree of LAD stenosis. The deficiency and LAD stenosis no correlation. And card, heart Yang deficiency with blood stasis and LAD stenosis have a positive correlation. Cardiac yang and left circumflex artery (LCX) stenosis has a positive correlation. There was no positive correlation between other syndromes and LCX stenosis. There is a positive correlation between the standard evidence and the degree of stenosis of right coronary artery (RA). Thereinto there is a positive correlation between cardiovascular stasis, phlegm stagnation, air slug and RA stenosis, and the relationship between cardiovascular stasis and the degree of stenosis Strongest. The deficiency and RA stenosis no correlation. Concurrent evidence, Yang deficiency with blood stasis, heart and yang deficiency associated with blood stasis, deficiency of heart and Qi combined with heart and blood stasis, yang deficiency with clotting and stagnation of blood and blood stasis and RA stenosis have a positive correlation. Conclusion: There is a positive correlation between the blood stasis syndrome of Yang-yang and the number of diseased vessels and the extent of vascular stenosis in patients with coronary artery disease. The correlation is strong and the correlation coefficient is large. It is verified that Professor Yan Dexin Coronary heart disease after restenosis of the basic pathogenesis "The correctness of this hypothesis.