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先天性畸形在史前人的遗骸中已见发现,然有关组织和器官的先天性异常则唯有依靠记载.公元前七世纪巴比伦的粘土书板就曾记载了心脏畸形.Neils Stensen在1671年详细描述了一例可能为法乐氏四联症的病
Congenital malformations have been found in the remains of prehistoric humans, but only in relation to the congenital anomalies of tissues and organs, heart deformities were recorded in clay tablets in Babylonian seventh century BC Neils Stensen detailed in 1671 Describes an example of a possible tetralogy of disease