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目的报道1例由冠状耳霉感染引起的虫霉病。方法病史及全面临床检查包括鼻部X线、CT、核磁共振(MRI)、鼻内镜等,排除其他肿瘤性疾病；病变部位组织活检,真菌直接镜检、培养、病理检查；临床用药治疗观察。结果组织病理检查见嗜酸细胞性肉芽肿,多核巨细胞内可见横断的壁薄而宽的菌丝,周围有(PAS染色)嗜酸性物质包裹(splendore-Hoeppli现象)。组织真菌培养可在平皿培养基背面见到与菌落形状相同的映象(弹射孢子形成的),显微镜下看到球彤孢子囊,锥状顶圆乳突,较多的小孢子囊冠及长柔毛孢子囊。经口服10％碘化钾20～30 mL每日3次,联合增效联磺片1．0g每日2次,治疗半个月后,瘙痒消失,皮损缩小。证实为冠状耳霉引起的虫霉病。结论冠状耳霉引起虫霉病为国内首报,碘化钾联合增效联磺片治疗有效。
Objective To report a case of Aspergillus mold caused by Coronillactosis. Methods Medical history and comprehensive clinical examination included nasal X-ray, computed tomography, magnetic resonance imaging (MRI) and endoscopic sinus surgery to exclude other neoplastic diseases; biopsy of lesions, direct microscopic examination of fungi, culture and pathological examination; . Results Histopathological examination revealed eosinophilic granuloma. Thin, wide mycelium was observed in the multinucleated giant cells, surrounded by (PAS staining) eosinophilic inclusions (splendore-Hoeppli phenomenon). Tissue fungal culture The same mapping of the colony shape (ejection spore formation) can be seen on the back of the plate culture medium, with conus parietal papillae, more papules and longer Pachyrhizi spores. Oral 10% potassium iodide 20 ~ 30 mL 3 times a day, combined with synergistic disulfide 1.0g 2 times a day, after treatment for half a month, the itching disappears, the lesion shrinks. Confirmation of Mycosis due to Coriaria. Conclusion Aspergillus flavus caused by Aspergillus is the first domestic report, potassium iodide combined with synergistic effect of sulfamethoxazole tablets.