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乳腺癌是女性常见恶性肿瘤,有部分患者会在手术很长时间后出现肿瘤复发和转移。日本国立癌症研究中心的科学家发现,乳腺癌长期休眠后复发与骨髓中特定物质的作用相关,接受手术治疗的乳腺癌患者,有的人会在10年甚至20年后出现复发。此前,有科学家认为,这是由于癌症干细胞移动到骨髓中并进入休眠状态,经过漫长岁月后复苏增殖所致,但其休眠和复苏机制一直没有被发现。日本国立癌症研究中心的一项研究显示,将骨髓中的间充质干细胞与乳腺癌细胞一起培养,发现间充质干细胞分泌的直径约100纳米(1
Breast cancer is a common malignant tumor in women. Some patients may have tumor recurrence and metastasis after a long period of operation. Scientists at Japan’s National Cancer Institute found that relapse after prolonged dormancy in breast cancer is linked to the role of specific substances in the bone marrow. Some breast cancer patients undergoing surgical treatment may relapse after 10 or even 20 years. Earlier, some scientists believe that this is due to cancer stem cells into the bone marrow and into the dormant state, after a long period of recovery and proliferation caused by, but the sleep and recovery mechanisms have not been found. A study by the National Cancer Institute of Japan showed that mesenchymal stem cells in bone marrow were cultured with breast cancer cells and found that mesenchymal stem cells secrete about 100 nm in diameter (1