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目的探讨自拟清血消白方联合西医治疗微小病变型肾病综合征的临床疗效。方法将2012年1月至2015年6月病理资料证实且首诊为微小病变型肾病综合征的100例患者,将患者随机分为对照组和观察组,各50例。对照组患者采用单纯常规西医治疗,观察组在对照组的治疗基础上联合应用自拟清血消白方。比较2组患者的临床治疗效果及蛋白尿和血脂水平变化。结果观察组患者有效率为90.00%,与对照组(70.00%)比较明显增加,差异有统计学意义(χ~2=9.22,P<0.05)。观察组患者治疗后24h尿蛋白定量[(0.52±0.10)g]、三酰甘油[(0.83±0.18)mmol/L]、胆固醇[(4.31±0.94)mmol/L]、肌酐[(120.11±10.12)μmol/L]、尿素氮[(4.02±0.77)mmol/L]与治疗前比较明显减少(t=7.66,7.38,7.91,8.55,7.72,P<0.05),清蛋白[(39.65±3.32)g/L]与治疗前比较明显增加(t=7.20,P<0.05),且各项指标与对照组比较,差异均有统计学意义(t=7.21,6.65,7.51,7.81,6.98,6.88,P<0.05)。结论自拟清血消白方联合西医治疗微小病变型肾病综合征临床效果明显,能显著改善患者肾功能和血脂水平,具有临床应用和推广价值。
Objective To investigate the clinical efficacy of Qingxu Xiao Bai Decoction combined with western medicine in the treatment of minimal-nephritic nephrotic syndrome. Methods From January 2012 to June 2015, 100 patients with pathologically confirmed minimal nephrotic syndrome were enrolled in the study. The patients were randomly divided into control group and observation group, with 50 cases in each group. The control group of patients with simple Western medicine treatment, the observation group in the control group based on the combined application of self-Qingxiao Bai side. The clinical effects and proteinuria and blood lipid levels in two groups were compared. Results The effective rate of the observation group was 90.00%, which was significantly higher than that of the control group (70.00%), the difference was statistically significant (χ ~ 2 = 9.22, P <0.05). Urinary protein quantitation [(0.52 ± 0.10) g], triglyceride [(0.83 ± 0.18) mmol / L], cholesterol [(4.31 ± 0.94) mmol / L] and creatinine [(120.11 ± 10.12 (4.02 ± 0.77) mmol / L] significantly decreased compared with those before treatment (t = 7.66,7.38,7.91,8.55,7.72, P <0.05) and albumin [(39.65 ± 3.32) g / L] significantly increased compared with those before treatment (t = 7.20, P <0.05), and the differences were statistically significant (t = 7.21,6.65,7.51,7.81,6.98,6.88, P <0.05). Conclusion Qingxu Xiao Bai Fang combined with Western medicine treatment of minimal-nephritic nephrotic syndrome has obvious clinical effect, can significantly improve renal function and blood lipid levels, with clinical application and promotion value.