多发性骨髓瘤(MM)是较为常见的造血系统恶性肿瘤,在美国年发病率为4/10万。我国MM发病率较低,但近年来有逐渐增高的趋势。骨痛、病理性骨折、贫血、出血、肾功能损害及反复感染等是本病的主要症状,部分患者还可以出现高钙血症、高粘滞综合征等,患者常因以上并发症导致死亡。因 Multiple myeloma (MM) is a more common hematopoietic malignancy with an annual incidence of 4/10 in the United States. MM incidence in China is low, but in recent years there is a gradual increase in the trend. Bone pain, pathological fractures, anemia, bleeding, renal damage and recurrent infections are the main symptoms of this disease, some patients may also appear hypercalcemia, hyperviscosity syndrome, etc., patients often cause death due to the above complications . because