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目的比较两种CF／5—FU合用方法的不良反应。方法把104例消化道恶性肿瘤患者分为两组，都给予含有CF／5—FU加顺铂等的联合化疗：A组66例CF静滴中途推注5—FU（疗法A），B组38例依次滴注CF和5—FU（疗法B），观察两种用法的不良反应。结果A组约1／3患者发生严重消化道粘膜损伤，口腔溃疡、腹痛腹泻和皮肤色素沉着明显高于B组（P＜0．005），其中5例死于不能控制的腹泻和发热所引起的休克。白细胞减少发生率也显著高于B组（P＜0．05）。B组只有13％患者出现一过性轻度腹泻，静脉炎的发生率显著高于A组（P＜0．005）。两种CF／5—FU用法不良反应有显著差异。结论疗法A可引起严重不良反应，建议谨慎使用。
Objective To compare the adverse reactions of two combined CF/5-FU methods. Methods One hundred and four patients with malignant tumors of the digestive tract were divided into two groups. All patients were given combined chemotherapy with CF/5-FU plus cisplatin: 66 CF infusions in group A were injected with 5-FU (treatment A), group B 38 patients were infused with CF and 5-FU (treatment B) in order to observe the adverse reactions of both usages. Results Approximately 1/3 of patients in group A developed severe gastrointestinal mucosal lesions, and oral ulcers, abdominal pain, diarrhea, and skin pigmentation were significantly higher than those in group B (P < 0.005), and 5 of them died of uncontrolled diarrhea and fever. Shock. The incidence of leukopenia was also significantly higher than that of group B (P<0.05). Only transiently mild diarrhea occurred in 13% of patients in group B, and the incidence of phlebitis was significantly higher than in group A (P<0.005). There were significant differences in the adverse effects of the two CF/5-FU administrations. Conclusion Treatment A can cause severe adverse reactions and it is recommended to use it with caution.