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分别合成主体分子聚β-环糊精和客体分子侧链含有金刚烷的聚合物,对其结构、分子量进行磁共振氢谱(~1H NMR)及凝胶渗透色谱(GPC)表征,并通过将主客体分子混合得到一种具有自我愈合能力且同时具有温度和pH双重敏感性的超分子水凝胶.研究发现,该水凝胶的相转变温度随着主/客体聚合物摩尔比的增加而提高,提高主/客体摩尔比、聚合物浓度和介质pH值有利于水凝胶的形成;水凝胶的溶胀率受聚合物浓度和水凝胶周围介质的pH值影响较大,体外药物释放具有pH响应性.基于主客体作用力的可逆性,该超分子水凝胶具有自愈合性.
Polymers of poly (β-cyclodextrin) and guest molecules containing adamantane were synthesized and their structures and molecular weights were characterized by 1H-NMR and GPC. Host-guest molecules are mixed to obtain a self-healing ability and at the same time have the dual sensitivity of temperature and pH of the supramolecular hydrogel study found that the phase transition temperature of the hydrogel with the host / guest polymer molar ratio increases Increasing and increasing the molar ratio of host to guest, the concentration of polymer and the pH value of the medium are conducive to the formation of hydrogel. The swelling rate of hydrogel is greatly affected by the concentration of polymer and the pH value of the medium surrounding the hydrogel, and the in vitro drug release With pH-responsiveness, the supramolecular hydrogel has self-healing properties based on the reversibility of host-guest forces.