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目的观察四逆散合左金丸联合雷贝拉唑治疗胃食管反流病的临床疗效。方法将96例胃食管反流病患者随机分为3组,中西药联合组36例服用四逆散合左金丸及雷贝拉唑;西药组30例单用雷贝拉唑;西药联合组30例服用铝碳酸镁及雷贝拉唑。3组疗程均为2周。观察各组患者治疗前后烧心、胸骨后疼痛、反酸、反食、咽部不适等症状的变化,并在治疗结束1个月后随访。结果3组患者治疗后症状总积分均较治疗前明显减少(P<0.01);中西药联合组总体疗效优于西药组(P<0.01),中西药联合组与西药联合组比较差异无统计学意义(P>0.05);3组治疗后单项症状积分均较治疗前明显下降(P<0.01),中西药联合组烧心、咽部不适症状改善优于西药组(P<0.05),胸骨后痛症状改善优于西药联合组(P<0.05)。治疗后1个月随访,中西药联合组在停药、抗复发方面优于西药组(P<0.01)。结论中药联合雷贝拉唑治疗胃食管反流病具有较好疗效,且复发率低。
Objective To observe the clinical efficacy of Sini San Zuo Jin Wan combined with Rabeprazole in the treatment of gastroesophageal reflux disease. Methods Ninety-six patients with gastroesophageal reflux disease were randomly divided into three groups: 36 cases in the combination group of Chinese and western medicine were treated with Siniosan with Zuojin pills and rabeprazole; 30 cases with western medicine alone with rabeprazole; 30 cases with western medicine combined group Cases of taking aluminum magnesium carbonate and rabeprazole. The three groups were treated for 2 weeks. The changes of heartburn, post-sternal pain, acid reflux, anti-diet and pharyngeal discomfort before and after treatment in each group were observed and followed up 1 month after the end of treatment. Results The total score of symptoms in the three groups after treatment was significantly lower than that before treatment (P <0.01). The overall curative effect of the combined traditional Chinese and western medicine group was better than that of the Western medicine group (P <0.01). There was no significant difference between the western medicine group and western medicine group (P <0.05). The scores of single symptom of three groups after treatment were significantly lower than those before treatment (P <0.01). The improvement of heartburn and throat discomfort in combination group was better than western medicine group (P <0.05) Symptoms were better than western medicine group (P <0.05). One month follow-up after treatment, the combination of Chinese and Western medicine was superior to Western medicine in withdrawal and anti-relapse (P <0.01). Conclusion Traditional Chinese medicine combined with rabeprazole in the treatment of gastroesophageal reflux disease has a good effect, and the recurrence rate is low.