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炔诺酮庚酸酯(NET-EN)是一种可注射的长效激素类避孕药。一些研究发现,炔诺酮庚酸酯不仅抑制排卵,且抑制子宫内膜而发挥其抗生育作用。本实验观察了注射NET-EN(200mg/60日)24个月后,子宫内膜组织学及血细胞计数的改变。 150名健康、有生育力印度妇女(18～35岁)在月经周期5天内,或流产1周和生产6周后,肌肉注射一次NET-EN油剂200mg/ml,以后每间隔60天注射一次。其间每名妇女在月经卡上记录阴道出血情况。治疗开始前及每次随访时详细询问病史并完成体检。在实验的第2、6、12和18个月,分别刮取子宫内膜做组织学检查;每次注射NET-EN前,均以肘前静脉取血测定血细胞总数和分类计数。
Norethindrone acetate (NET-EN) is an injectable long-acting hormonal contraceptive. Some studies have found that norethindrone heptanoate not only inhibits ovulation, but also inhibits the endometrium to exert its anti-fertility effect. This experiment observed the changes of endometrial histology and blood cell count after 24 months of injection of NET-EN (200mg / 60day). 150 healthy, fertile Indian women (18-35 years) were given intramuscular injections of 200 mg / ml NET-EN oil 5 days after the menstrual cycle or 1 week after abortion and 6 weeks after production, and then injected once every 60 days . During this period, each woman recorded vaginal bleeding on the menstruation card. Before treatment and at each follow-up detailed history and medical examination completed. At the 2nd, 6th, 12th and 18th months of the experiment, the endometrium was scraped for histological examination. Before the injection of NET-EN, the blood samples were taken from the antecubital vein to determine the total number of blood cells and the classification and count.