Objective To evaluate the effect and toxicological reactions of Duoruifen in the management of cancer Pain. Method Transfer Fentanyl with trade name Duoruifen was applied to control chronically moderate to severe cancer pain in 65 cases. Change of drug was conducted once 72 hours, for 30～ 120 days. Observation indexes included pain intensity, relief rate, life satisfaction, quality of life, etc..Result Relief for moderate and severe cancer pain was 88.63% and 80.95% ,respectively.Alteration intercourse for 21.54% patients was reduced,and satisfaction was 93.84% . Quality of life was markedly improved. Incidence of constipation, vomiting, dizziness and nausea was 13.84% ,10.76% ,7.69% and 7.69% respectively.Conclusion Duoruifen is capable of effectively controlling cancer pain with good acceptability, adverse effect patients willing to accept it.