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[目的]探讨铟锡氧化物(ITO)对大鼠体内铁、锌、铜元素含量的影响。[方法]选取SPF级Wistar雄性大鼠24只,随机分为对照组、ITO 3 mg/kg组和ITO 6 mg/kg组。对染毒组大鼠进行肺灌注染毒,每周2次,连续染毒8周。染毒结束后,在屏障环境下继续喂养8周。造模结束后立即处死大鼠,摘取其肺脏、肝脏、肾脏、心脏、脾脏和股骨,经微波消解处理后,采用电感耦合等离子体质谱法测定铟、铁、锌、铜元素含量。[结果]与对照组相比,ITO 3 mg组和6 mg组大鼠肺脏、肝脏、心脏、脾脏、股骨铟含量均更高(均P<0.05),肺脏、肾脏中锌含量更低(均P<0.05),肺脏、肝脏中铁含量更低(均P<0.05);ITO 6 mg组大鼠肺脏、肝脏和肾脏中铜/锌值均高于对照组(P<0.05)。[结论]ITO染毒可降低大鼠肺脏组织中锌、铁含量,使铜/锌值升高,进而干扰大鼠体内微量元素的平衡。
[Objective] To investigate the effects of indium tin oxide (ITO) on the content of iron, zinc and copper in rats. [Method] Twenty-four Wistar male rats were randomly divided into control group, ITO 3 mg / kg group and ITO 6 mg / kg group. The rats in the exposure group were exposed to pulmonary perfusion twice a week for 8 weeks. After the exposure, continue to feed in the barrier environment for 8 weeks. Rats were sacrificed immediately after modeling, and their lungs, liver, kidney, heart, spleen and femur were harvested. After microwave digestion, the contents of indium, iron, zinc and copper were determined by inductively coupled plasma mass spectrometry. [Results] Compared with the control group, the content of indium in the lung, liver, heart, spleen and femur in the ITO 3 mg group and the 6 mg group were higher (both P <0.05) and lower in the lungs and kidneys (P <0.05). The contents of Fe and Fe in lung and liver were lower in ITO 6 mg group than those in control group (P <0.05). [Conclusion] ITO can reduce the content of zinc and iron in the lung tissue of rats, and increase the copper / zinc value, then disturb the balance of trace elements in rats.