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钙拮抗药(calcium channel blockers,CCB)又称Ca~(2+)拮抗药,能阻断细胞膜上的钙通道,阻止钙离子流入细胞内,降低细胞内钙离子浓度,阻断平滑肌细胞的兴奋-收缩偶联,使平滑肌松弛,从而能解除血管、呼吸道、消化道、泌尿生殖道以及肝胆胰肾等平滑肌组织器官的痉挛,常用于心绞痛、高血压、心律失常等心血管疾病的治疗。随着对各种疾病发病机理认识的不断加深和CCB药理机制的不断明确,CCB的临床应用正在向除心血管外的其他领域不断扩展。现将其临床新用途综述如下。1 CCB在肾科疾病中的应用有学者认为CCB对急性肾功能衰竭(ARF)、慢性肾
Calcium channel blockers (CCBs), also known as Ca2 + antagonists, block the calcium channels in the cell membrane, prevent the influx of calcium ions into cells, reduce the intracellular calcium concentration, and block the excitability of smooth muscle cells - Shrinkage coupling, the smooth muscle relaxation, which can relieve blood vessels, respiratory tract, digestive tract, genitourinary tract and hepatobiliary pancreas and other smooth muscle and organ spasm, commonly used in the treatment of angina pectoris, hypertension, arrhythmia and other cardiovascular diseases. With the deepening understanding of the pathogenesis of various diseases and CCB pharmacological mechanisms continue to be clear, the clinical application of CCB is to other areas in addition to cardiovascular expansion. Now its clinical new uses are summarized below. 1 CCB in the application of kidney disease Some scholars believe that CCB acute renal failure (ARF), chronic kidney