丙戊酸(VPA)是最近几年才广泛用于临床的一种广谱抗癫痫药,1882年首次由Burton 合成;但直到1963年才由 Meunien 等人证实有抗惊厥的特性。1978年在美国被正式允许作为一种抗癫痫药。现广泛用于控制癫痫的各种发作类型,尤其是全身性发作的治疗。近十年,特别是八十年代以来不少学者对其抗癫痫的作用机制做了大量的研究,归纳起来主要有以下三种学说。 VPA is a broad-spectrum antiepileptic drug that has been widely used clinically in recent years and was first synthesized by Burton in 1882; anticonvulsant was not confirmed until 1963 by Meunien et al. In 1978 in the United States was officially allowed as an antiepileptic drug. Now widely used to control various types of epilepsy seizures, especially the treatment of generalized seizures. In the last ten years, especially since the eighties many scholars did a great deal of research on the mechanism of their anti-epilepsy, and summed up the following three theories.