雌激素与神经营养因子一样 ,在促进神经元的分化和存活 ,保护神经元 ,维持正常的功能等方面有重要作用。雌激素替代治疗能保护胆碱能神经元 ,改善认知功能和记忆 ,但对其作用的机理尚未完全了解。一般认为通过神经营养因子及其受体的相互调节 ,作用于相应的信号转导途径 Estrogen, like neurotrophic factors, plays an important role in promoting neuronal differentiation and survival, protecting neurons and maintaining normal function. Estrogen replacement therapy can protect cholinergic neurons, improve cognitive function and memory, but its mechanism of action is not yet fully understood. Generally believed that through the regulation of neurotrophic factors and their receptors, acting on the corresponding signal transduction pathway