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正常情况下酸性胃液的消化侵袭作用和胃粘膜的防护机制处于平衡状态,一旦平衡打破则发生消化性溃疡。胃粘膜具有一系列防御机能:(1)粘液—碳酸氢盐屏障:胃粘膜分泌的粘液形成粘蛋白凝胶;胰十二指肠分泌的碱性碳酸盐液使粘膜上皮表面pH保持中性。(2)粘膜屏障:一般认为指胃粘膜上皮细胞腔面胞
Under normal circumstances the digestion and invasion of acid gastric juice and gastric mucosal protective mechanism in a balanced state, once the balance is broken peptic ulcer occurs. Gastric mucosa has a series of defensive functions: (1) Mucus-bicarbonate barrier: Mucus secreted by the gastric mucosa forms mucins; alkaline carbonate secreted by the pancreatic duodenum keeps the mucosal epithelial surface pH neutral . (2) mucosal barrier: generally considered to mean mucosal epithelial cells cavity cells