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白细胞介素 (IL) 1 6是一种可由多种细胞合成和分泌的前炎症细胞因子 ,它通过与其受体结合后导致多种炎性细胞的浸润和活化 ,从而在哮喘气道炎症反应的发生发展中起了重要的作用。最近研究表明 ,IL 1 6不仅与哮喘气道慢性炎症反应、气道高反应性和IgE的上调有关 ,而且哮喘患者血清、痰液、组织细胞及支气管肺泡灌洗液中IL 1 6的表达和分泌的动态变化与哮喘气道炎症反应的发生发展和转归密切相关。因此 ,本文就IL 1 6的生物学特点及其与支气管哮喘关系作一综述 ,以探讨通过抑制IL 1 6的作用来治疗哮喘的可能性及前景
Interleukin (IL) 16 is a proinflammatory cytokine that can be synthesized and secreted by a variety of cells, which, upon binding to its receptor, causes the infiltration and activation of a variety of inflammatory cells, Occurrence of development has played an important role. Recent studies have shown that IL-6 is not only associated with chronic airway inflammation, airway hyperresponsiveness and IgE upregulation in asthma, but also IL-6 expression in serum, sputum, tissue cells and bronchoalveolar lavage fluid in asthmatic patients and The dynamic changes of secretion are closely related to the occurrence, development and prognosis of airway inflammation in asthma. Therefore, the biological characteristics of IL-6 and its relationship with bronchial asthma are reviewed in this paper to explore the possibility and prospect of treating asthma by inhibiting IL-6