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目的观察脑还丹对快速老化(SAMP/8)小鼠学习记忆能力的影响。方法用6月龄雄性SAMP/8小鼠随机等分为脑还丹高、低剂量组和模型组,6月龄正常老化(SAMR/1)小鼠为正常对照组。给药8周后,运用Morris水迷宫方法测试各组小鼠的定位航行和空间探索能力。结果 SAMP/8小鼠的学习记忆能力明显低于同月龄SAMR/1小鼠,表现为逃避潜伏期从第2天起显著延长,原平台象限停留时间缩短。给予脑还丹8周治疗,SAMP/8小鼠逃避潜伏期明显缩短(P<0.001~0.05)。原平台象限停留时间明显延长(P<0.001~0.05),且有一定的量效关系(P<0.05)。结论脑还丹能显著改善SAMP/8小鼠方向辨别的学习能力及记忆巩固、再现能力。
Objective To observe the effects of Naoxu Dan on learning and memory abilities in mice with rapid aging (SAMP / 8). Methods Male 6-month-old male SAMP / 8 mice were equally divided into high dose and low dose groups and model group. Six-month-old normal aging (SAMR / 1) mice were used as normal control group. After 8 weeks of administration, Morris water maze method was used to test the positioning navigation and space exploration ability of each group of mice. Results The learning and memory ability of SAMP / 8 mice was significantly lower than that of SAMR / 1 mice of the same age. The escape latency was significantly prolonged from the second day and the residence time of the original platform quadrant was shortened. After given BLD for 8 weeks, the escape latency of SAMP / 8 mice was significantly shortened (P <0.001 ~ 0.05). The original platform quadrant residence time was significantly prolonged (P <0.001 ~ 0.05), and have a certain dose-effect relationship (P <0.05). Conclusion Naohuan Dan can significantly improve learning ability and memory consolidation and reproduction ability in SAMP / 8 mice.