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目的:考察盐酸多巴胺注射液与注射用托拉塞米的配伍稳定性。方法:采用液相色谱法,对盐酸多巴胺注射液与注射用托拉塞米的配伍液进行定性和定量分析,考察其配伍液的稳定性变化。结果:两种药物混合后出现颜色变化;注射用托拉塞米峰面积响应值未见明显变化,而盐酸多巴胺峰面积响应值明显下降,提示盐酸多巴胺可能发生了化学反应。结论:在治疗顽固性心衰时,虽然托拉塞米与盐酸多巴胺联用有较好的疗效,但在应用时应注意两药存在配伍禁忌,避免在同一静脉通道内静脉滴注。
Objective: To investigate the compatibility of dopamine hydrochloride injection and torsemide for injection. Methods: Liquid chromatography was used to qualitatively and quantitatively analyze the compatibility of dopamine hydrochloride injection and torsemide for injection. The stability of compatibility solution was investigated. Results: There was a color change after the mixture of two drugs. There was no significant change in the peak area of torasemide for injection, but the response value of dopamine hydrochloride peak area decreased significantly, suggesting that chemical reaction may occur in dopamine hydrochloride. Conclusion: In the treatment of refractory heart failure, although torsemide combined with dopamine hydrochloride has a good effect, but should pay attention to the compatibility of the two drugs incompatibility, to avoid intravenous drip in the same vein channel.