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抗结核药物对肝脏的损害临床上屡见不鲜,但造成肝功衰竭并致死者并不常见,我院10年中遇4例。为吸取教训,现报告如下: 例1 男,20岁,诊断:Ⅲ(上0中0)/(-)(+)进展,SGPT350u(正常≤100u),HBsAg(+)开始用PAS,SM加RFP或RFD,104天后出现肝病症状,SGPT540u,SB102.6μmol/L,HBsAg~(+++)。又29天后死于肝功衰竭伴MOFF,死后肝穿诊断①慢活肝伴亚急性肝坏死;②肝硬化伴广泛淤胆。
Antituberculosis drugs on the liver damage is clinically common, but caused by liver failure and death are not common, 10 cases in our hospital in 4 cases. To learn the lesson, the report is as follows: Example 1 Male, 20 years old, diagnosis: Ⅲ (0 in 0) / (-) (+) progress, SGPT350u (normal ≤100u), HBsAg RFP or RFD, symptoms of liver disease after 104 days, SGPT540u, SB102.6μmol / L, HBsAg ~ (+++). 29 days later died of liver failure with MOFF, diagnosis of death after liver wear ① slow living liver with subacute hepatic necrosis; ② cirrhosis with extensive cholestasis.