论文部分内容阅读
慢性静脉回流障碍患者常服用血管性药物Venocuran(成分为印度栗、吡唑啉酮、甘油)治疗,最近发现该药与假性狼疮有明显关系。本文报道8例假性狼疮,均女性,25～69岁。8例都有发热,心包炎及/或心肌病变;7例血沉、α_2、γ球蛋白增高;6例有胸膜病变;4例有关节痛及/或肌痛或肺部浸润,但抗核抗体均阴性;抗线粒体抗体均阳性。水杨酸、强的松治疗有效。实验室检查尚见4例白细胞超过1万/立方毫米,2例淋巴细胞低于15/立方毫米,肝酶谱,胆红素,凝血酶原,IgA、G、M,补体3、4均正常,细菌血培养阴性。文献上类似病例曾报导过117例。临床上可分二种类型,①轻型,病程短(1～3月),早期抗体阴性;②慢性进行型,其特点为有发作期,间有无症状
Patients with chronic venous reflux disorders often take the vascular drug Venocuran (ingredients chestnut, pyrazolone, glycerol) treatment, recently found that the drug has a clear relationship with the pseudo-lupus. This article reports 8 cases of pseudo-lupus, all women, 25 to 69 years old. 8 cases had fever, pericarditis and / or cardiomyopathy; 7 cases of erythrocyte sedimentation rate, α_2, γ globulin increased; 6 cases of pleural disease; 4 cases of arthralgia and / or myalgia or pulmonary infiltration, but anti-nuclear antibody All were negative; anti-mitochondrial antibodies were positive. Salicylic acid, prednisone effective treatment. Laboratory tests also see 4 cases of leukocytes more than 10,000 / cubic mm, 2 cases of lymphocytes below 15 / cubic mm, liver enzymes, bilirubin, prothrombin, IgA, G, M, complement 3, 4 were normal , Bacterial blood culture negative. 117 similar cases have been reported in the literature. Clinically divided into two types, ① light, short duration (1 to 3 months), early antibody negative; ② chronic progressive type, which is characterized by an attack period, asymptomatic