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目的:分析探讨采用小剂量氢氯噻嗪(12.5mg)治疗轻度高血压临床疗效,并比较其与硝苯地平缓释片(10mg)对轻度高血压(收缩压为140-159mmhg,舒张压为90-99mmhg)降压的有效性。方法:回顾性分析本院2013年12月-2014年12月就诊的的1000例高血压患者,根据临床检查诊断结果,将其随机分为对照组(硝苯地平缓释片10mg)和试验组(小剂量氢氯噻嗪12.5mg),每组各500例。两组患者均根据国际标准测量血压(mmhg),口服硝苯地平缓释片与小剂量氢氯噻嗪进行治疗,分析比较两组患者的临床治疗结果,以及临床安全性和不良反应发生率。结果:两组患者的血压下降情况相比无显著性差异(P>0.05);实验组患者的不良反应主要表现为低血钾,试验组患者的临床不良反应发生率与对照组患者无显著差异,具有统计学意义(P>0.05)。结论:采用小剂量氢氯噻嗪治疗轻度高血压具有显著的疗效。但是,使用过程中应该检测电解质,以免引起低血钾。
Objective: To investigate the clinical efficacy of low dose hydrochlorothiazide (12.5 mg) in the treatment of mild hypertension and to compare it with nifedipine sustained release tablets (10 mg) for mild hypertension (systolic blood pressure 140-159 mmhg, diastolic blood pressure 90 -99mmhg) the effectiveness of antihypertensive. Methods: A retrospective analysis of our hospital from December 2013 to December 2014 for the treatment of 1000 cases of hypertensive patients, according to clinical examination results, were randomly divided into control group (nifedipine sustained-release tablets 10mg) and the experimental group (Low-dose hydrochlorothiazide 12.5mg), 500 cases in each group. The two groups of patients were measured according to international standards of blood pressure (mmhg), oral nifedipine sustained-release tablets and low-dose hydrochlorothiazide for treatment, analysis of two groups of patients with clinical treatment, and clinical safety and adverse reactions. Results: There was no significant difference in blood pressure drop between the two groups (P> 0.05). Adverse reactions in the experimental group mainly manifested as hypokalemia. The incidence of clinical adverse reactions in the experimental group was not significantly different from that in the control group , With statistical significance (P> 0.05). Conclusions: The use of small doses of hydrochlorothiazide in the treatment of mild hypertension has a significant effect. However, the electrolyte should be tested during use to avoid hypokalemia.