论文部分内容阅读
应用免疫组织化学及放免分析方法,对饲予克山病病区粮大鼠胰岛的形态与机能研究结果表明:低硒的克山病病区粮可引起大鼠血清胰岛素、C肽水平明显下降,胰岛内C肽和胰岛素分泌贮备显著减少,并出现胰岛β细胞萎缩、变性等形态学损害。在病区粮内补一定剂量硒或维生素E(VE)可明显提高血清胰岛素、C肽水平,增加β细胞分泌贮备,提示硒和VE缺乏引起的过氧化损害可能是胰岛受损的主要机制。本研究结果提示克山病基本病因可引起胰岛的原发性损害,其作为克山病发病过程中的重要环节,可能对心肌坏死的发生发展起一定作用。
Immunohistochemistry and radioimmunoassay methods were used to study the morphology and function of pancreatic islets in rats fed with Keshan disease. The results showed that the serum and insulin levels and C-peptide levels of rats in Keshan disease group were significantly decreased , The islet C peptide and insulin secretion reserve decreased significantly, and pancreatic β cell atrophy, degeneration and other morphological damage. Supplementation of a dose of selenium or vitamin E (VE) in the ward can significantly increase the levels of serum insulin and C-peptide and increase the secretion of β cells, suggesting that the main mechanism of islet damage may be the over-oxidative damage caused by selenium and VE deficiency. The results suggest that the basic etiopathogenisis of Keshan disease can cause primary damage of islets, which plays an important role in the pathogenesis of Keshan disease and may play a role in the occurrence and development of myocardial necrosis.