【摘 要】
：
An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. wa
【机 构】
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Department of Organic Chemistry,School of Chemistry,Madurai Kamaraj University,Department of Microbi
【出 处】
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Chinese Chemical Letters
论文部分内容阅读
An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent.
An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. Water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz . Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In the marketed drug tetracycline, some of them are equally potent and a few are more potent.
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