在身材矮小的病因中 ,相当多的是由于生长激素所造成 ,定义为生长激素缺乏症 (ＧＨＤ) ,其发病率约为 1/ 10 0 0 0～1/ 40 0 0。通过生长激素 (ＧＨ)治疗儿童ＧＨＤ已近半个世纪。最初人们从人垂体纯化提取ＧＨ(ｐｈＧＨ) ,2 0世纪 80年代后发现ｐｈＧＨ可导致儿童发生早老性痴 In the short stature of the cause, a considerable number is due to growth hormone, which is defined as growth hormone deficiency (GHD), the incidence of about 1/100 ~ 1/40 0 0. GHD has been treated in children for nearly half a century through growth hormone (GH). Initially, people extracted pituitary GH (phGH) from the 20th century, 80 years after the found that phGH can lead to premature children