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目的应用血液流动可视化技术(MC-FAN)观察血脂异常患者的血流状态和血流时间(TT),探讨患者血脂水平、血液流变学指标和炎症因子水平与TT之间的相关性。方法确诊血脂异常患者98例,空腹常规检测其血脂水平、血液流变学指标及炎症因子指标,应用逐步多元回归分析统计方法对其与血液流动可视化测定TT进行相关性分析比较。结果血脂异常患者测定的TT(25μl)、TT(50μl)、TT(75μl)、TT(100μl)和健康对照组比较有显著差异(P<0.05)、非常显著差异(P<0.01);其中分别与总胆固醇(TC)呈正相关(r=0.235,P=0.038;r=0.246,P=0.041;r=0.258,P=0.038;r=0.218,P=0.044);TT(25μl)、TT(50μl)分别与甘油三酯(TG)呈正相关(r=0.216,P=0.048;r=0.215,P=0.043);TT(25μl)、TT(50μl)和TT(75μl)分别与高密度脂蛋白胆固醇(HDL-C)呈负相关(r=-0.269,P=0.032;r=-0.277,P=0.035;r=-0.262,P=0.039);TT(75μl)和TT(100μl)分别与血浆黏度(PV)呈正相关(r=0.320,P=0.045;r=0.254,P=0.045);TT(100μl)与红细胞聚集指数(EI)呈正相关(r=0.267,P=0.008)。TT(25μl)和TT(75μl)分别与腰围(WC)及体重指数(BMI)呈正相关(r=0.231,P=0.023,r=0.181,P=0.046)。TT(25μl)、TT(50μl)和TT(100μl)分别与细胞间黏附因子-1(ICAM-1)呈正相关(r=0.261,P=0.020;r=0.244,P=0.030;r=0.172,P=0.029)。结论血脂异常患者的血液流动性可视化检测(MC-FAN)血液流动时间(TT)与健康人有显著差异,其中部分TT与血脂、血液流变学指标、炎症指标水平、体格指数之间存在相关性,血液流变学可视化检测技术可作为判断血脂异常患者血流状况的参考指标。
Objective To observe the blood flow state and blood flow time (TT) in patients with dyslipidemia by using the blood flow visualization technique (MC-FAN) to explore the correlation between the levels of blood lipids, hemorheological indexes and inflammatory cytokines in TT patients. Methods 98 cases of dyslipidemia patients were diagnosed as fasting blood lipids, hemorrheological indexes and inflammatory cytokines by routine fast multiple regression analysis, and their correlation with blood flow visualization TT was analyzed by stepwise multiple regression analysis. Results There was a significant difference (P <0.05) between TT (25μl), TT (50μl), TT (75μl), TT (100μl) and healthy control in patients with dyslipidemia Was positively correlated with total cholesterol (TC) (r = 0.235, P = 0.038; r = 0.246, P = 0.041; r = 0.258, P = 0.038; ) Were positively correlated with triglyceride (TG) (r = 0.216, P = 0.048; r = 0.215, P = 0.043). TT (25μl), TT (R = -0.277, P = 0.035; r = -0.262, P = 0.039); TT (75μl) and TT (100μl) were negatively correlated with plasma HDL-C (P = 0.045; r = 0.254, P = 0.045). There was a positive correlation between TT (100μl) and erythrocyte aggregation index (r = 0.267, P = 0.008) TT (25μl) and TT (75μl) were positively correlated with waist circumference (WC) and body mass index (BMI) (r = 0.231, P = 0.023, r = 0.181, P = 0.046). TT (25μl), TT (50μl) and TT (100μl) were positively correlated with ICAM-1 (r = 0.261, P = 0.020; P = 0.029). Conclusion The blood flow visualization test (MC-FAN) showed significant difference in blood flow time (TT) between healthy people and patients with dyslipidemia. Some TT were correlated with serum lipids, hemorheology indexes, inflammation index and body mass index Sexual, hemorheological visualization detection techniques can be used as a reference index to determine the blood flow in patients with dyslipidemia.