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目的对国际肝干细胞研究文献进行可视化分析,为把握重点研究方向、选择前沿技术课题、进行科学合理的科技布局提供决策信息支持。方法利用文献计量学方法和信息可视化方法对WebofScience中的SCIE数据库收录的国际肝干细胞研究文献的时间、国别、机构、期刊、学科、主题进行分析。结果科学引文索引扩展版(SCIE)收录了1092篇肝干细胞研究文献,自2000年开始文献数量进入快速增长期;在文献数量上中国与美国、日本差距较大;肝干细胞研究属多学科交叉领域,但发表期刊相对集中;其研究基本上经历了肝干细胞的发现辨认、来源和基础应用研究阶段;研究前沿有肝干细胞的识别和移植后鉴定、参与肝再生机制、诱导分化、外源基因的表达等。结论中国应加大肝干细胞资金投入、加强与顶级科研院所的交流合作、自主创新,引导肝干细胞从基础研究向临床研究转化。
Objective To visualize international liver stem cell research literature and provide decision-making information support for grasping key research directions, selecting cutting-edge technical topics and conducting scientific and rational technological layout. Methods Bibliometrics and information visualization methods were used to analyze the time, country, institution, periodical, discipline and subject of international liver stem cell research literature collected by SCIE database in WebofScience. Results SCI included 1092 articles on liver stem cell research, and the number of literatures began to increase rapidly in 2000; the number of the literature was quite different between China and the United States and Japan; the research on hepatic stem cells was a multidisciplinary field , But the published journals are relatively concentrated. The research has basically undergone the identification of liver stem cells, the source and the basic application of the research phase; the research front identified the liver stem cells and identified after transplantation, involved in liver regeneration mechanism, induced differentiation, foreign genes Expression and so on. Conclusion China should increase funding for liver stem cells, strengthen exchanges and cooperation with top research institutes, innovate independently and guide the transformation of liver stem cells from basic research to clinical research.