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目的：探讨Ｂｃｌ－２蛋白在子宫内膜癌组织中的表达及其临床意义。方法：应用免疫组化法测定对５０份子宫内膜癌石蜡包埋标本Ｂｃｌ－２蛋白的表达。结果：Ｂｃｌ－２蛋白在子宫内膜癌组织中的表达阳性率为４８．００％（２４／５０），其阳性表达与子宫内膜癌的组织学分级、肌层浸润深度及患者预后有关（Ｐ＜０．０５），与子宫内膜癌临床分期、组织学类型及病理学类型无关。结论：Ｂｃｌ－２蛋白表达与子宫内膜癌的某些病理学特征及生物学行为之间有相关性。应用免疫组化法测定Ｂｃｌ－２蛋白表达对判断子宫内膜癌患者的预后有一定的价值。
Objective: To investigate the expression of Bcl-2 protein in endometrial carcinoma and its clinical significance. Methods: The expression of Bcl-2 protein in 50 samples of endometrial carcinoma paraffin-embedded specimens was detected by immunohistochemistry. Results: The positive rate of Bcl-2 protein expression in endometrial carcinoma was 48.00% (24/50). The positive expression of Bcl-2 protein correlated with the histological grade, the depth of myometrial invasion and the prognosis P <0.05), and the clinical stage, histological type and pathological type of endometrial cancer has nothing to do. Conclusion: There is a correlation between the expression of Bcl-2 protein and some pathological features and biological behavior of endometrial carcinoma. The application of immunohistochemistry in the determination of Bcl-2 protein expression in judging the prognosis of patients with endometrial cancer has a certain value.