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目的探讨核糖核苷酸还原酶小亚基(p53R2)在卵巢上皮性肿瘤中的表达及其临床病理意义。方法应用免疫组织化学方法检测66例上皮性卵巢癌组织,20例上皮性卵巢交界性肿瘤组织、36例上皮性卵巢良性肿瘤组织、20例卵巢组织中p53R2蛋白的表达情况,并分析其与卵巢癌临床病理特征的关系。结果免疫组化检测结果显示,上皮性卵巢癌组织中p53R2蛋白表达阳性率为72.7%(48/66),交界性上皮性卵巢肿瘤中为50%(10/20),卵巢上皮性良性肿瘤组织中为46%(15/36),正常卵巢组织为5%(1/20);低分化肿瘤组织中p53R2蛋白表达阳性率显著高于中、高分化者(P<0.05);并发肝转移的癌组织中p53R2表达高于无肝转移组(P<0.01);p53R2蛋白表达与有无淋巴结转移无关(P>0.05);p53R2蛋白高表达者,术后生存时间短(P<0.05)。结论上皮性卵巢癌中p53R2蛋白表达阳性率明显增高,并与卵巢癌病情进展有关,可望作为卵巢癌患者独立的预后指标。
Objective To investigate the expression of ribonucleotide reductase small subunit (p53R2) in ovarian epithelial tumors and its clinicopathological significance. Methods Immunohistochemistry was used to detect the expression of p53R2 protein in 66 cases of epithelial ovarian cancer, 20 cases of epithelial ovarian borderline tumor, 36 cases of epithelial ovarian benign tumor and 20 cases of ovarian tissue. Relationship between clinicopathological characteristics and cancer. Results The positive rate of p53R2 protein expression in epithelial ovarian cancer was 72.7% (48/66), in borderline epithelial ovarian tumors (50%, 10/20), in ovarian epithelial benign tumor tissues (46%, 15/36) and normal ovarian tissue (5%, respectively). The positive rate of p53R2 protein expression in poorly differentiated tumor tissues was significantly higher than that in moderately differentiated and poorly differentiated tumors (P <0.05) The expression of p53R2 in cancer tissue was higher than that in non-liver metastasis group (P <0.01). The expression of p53R2 protein had no correlation with lymph node metastasis (P> 0.05). The high expression of p53R2 protein had a shorter postoperative survival time (P <0.05). Conclusions The positive rate of p53R2 protein in epithelial ovarian cancer is significantly higher than that in ovarian cancer, which may be an independent prognostic indicator in patients with ovarian cancer.