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背景:关于动脉粥样硬化的发病机制研究者多关注脂质代谢紊乱的变化和情况。但以血液流变学指标与血脂指标水平的关联分析研究报道较少。目的:探讨血液流变学指标,血清脂蛋白a等血脂其他指标水平及其相关性与血栓性疾病的关系。设计:以诊断为依据的病例对照研究。地点和对象:选择2001-08/2002-10在武汉大学中南医院神经内科确诊的脑梗死患者(脑梗死组)68例(年龄49～81岁,男42例,女26例)。在武汉大学中南医院心血管内科确诊的心肌梗死患者(心肌梗死组)49例(年龄50～87岁,男29例,女20例)。对照组为无心、脑血管疾病的健康志愿者及献血员98例(年龄43～76岁,男56例,女42例)。方法:对68例脑梗死患者、49例心肌梗死患者、98例健康对照组进行血液流变学指标和脂蛋白a等其他各血脂指标的检测,并进行统计学分析。主要观察指标:血液流变学指标和脂蛋白a等其他血脂指标。结果:脑梗死组和心肌梗死组总胆固醇、三酰甘油,高密度脂蛋白胆固醇、脂蛋白a水平均明显高于对照组(t=2.48～2.70,P<0.01);低密度脂蛋白胆固醇明显低于对照组(t=2.63～2.66,P<0.01);载脂蛋白A1、载脂蛋白B与对照组比较,差异无显著性意义(t=0.89～1.39,P>0.05);脑梗死组和心肌梗死组血液流变学指标显著高于对照组(t=2.43～2.65,P<0.01);且心肌梗死组
Background: The pathogenesis of atherosclerosis Researchers are mostly concerned with the changes and conditions of lipid metabolism disorders. However, there are few reports on the correlation analysis between hemorheology index and blood lipid level. Objective: To investigate the relationship between hemorrheological parameters, serum lipoprotein a and other indexes and their correlation with thrombotic diseases. Design: A case-control study based on diagnosis. Location and Subjects: A total of 68 patients (aged 49-81 years, 42 males and 26 females) with cerebral infarction (cerebral infarction group) diagnosed at Department of Neurology, Zhongnan Hospital of Wuhan University from August 2001 to October 2002 were selected. 49 cases (50 to 87 years old, 29 males and 20 females) of myocardial infarction patients (myocardial infarction group) diagnosed by Department of Cardiology of Zhongnan Hospital of Wuhan University. In the control group, there were 98 healthy volunteers and blood donors without heart and cerebrovascular disease (aged 43-76 years, 56 males and 42 females). Methods: The hemorrheological parameters and other lipoprotein a and other lipids were measured in 68 patients with cerebral infarction, 49 patients with myocardial infarction and 98 healthy controls. Statistical analysis was performed. MAIN OUTCOME MEASURES: Hemorheology and other lipids such as lipoprotein a. Results: The levels of total cholesterol, triglyceride, high density lipoprotein cholesterol, and lipoprotein a in cerebral infarction group and myocardial infarction group were significantly higher than those in control group (t = 2.48-2.70, P <0.01); LDL cholesterol was significantly (T = 0.89-1.39, P> 0.05). Compared with the control group, the levels of apolipoprotein A1 and apolipoprotein B in the cerebral infarction group were significantly lower than those in the control group (t = 2.63-2.66, And myocardial infarction group were significantly higher than the control group (t = 2.43 ~ 2.65, P <0.01); and myocardial infarction group