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对 6 9例良、恶性腹水中甘氨酰脯氨酸二肽氨基肽酶 (GPDA)进行检测 ,并与 Tch、CEA检测比较。结果显示腹水 GPDA在恶性腹水组明显高于良性腹水组 ,分别为 5 5 .2± 30 .0 u/ ml和 19.8± 17.3u/ ml,P<0 .0 1。以 >35 u/ ml为界值诊断恶性腹水的敏感性为 94.4%,特异性为 96 .9%与 Tch相似 (P>0 .0 5 ) ,而明显优于 CEA,(P<0 .0 1)。研究表明 :腹水 GPDA为恶性腹水的新标记 ,其价值不亚于甚或略优于腹水总胆固醇
Sixty-nine cases of benign and malignant ascites were tested for glycyl-proline dipeptide aminopeptidase (GPDA) and compared with Tch and CEA tests. The results showed that ascites GPDA was significantly higher in the malignant ascites group than in the benign ascites group (55.2 ± 30.0 u/ml and 19.8 ± 17.3 u/ml, respectively; P < 0.01). The sensitivity of diagnosing malignant ascites with a value of >35 u/ml was 94.4%, and the specificity was 96.9% similar to Tch (P>0.05), but significantly better than that of CEA (P<0. 0 1). Studies have shown that: Ascites GPDA is a new marker of malignant ascites, its value is as good as or slightly better than ascites total cholesterol