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采用铈盐-羟基氧化还原引发体系,在交联聚乙烯醇(CPVA)微球表面引发接枝聚合对苯乙烯磺酸钠(SSS),制备了接枝聚阴离子的功能接枝微球CPVA-g-PSSS,研究了其对5-氨基水杨酸(5-ASA)的吸附(载药)性能、机理和释放行为.结果表明,在酸性介质中,受强静电相互作用驱动,CPVA-g-PSSS对5-ASA分子表现出很强的吸附能力,吸附容量达39.1mg/g,可实现有效载药.载药微球的释药行为具有强烈的pH值依赖性,在pH=1的介质中基本不释药,而在pH=7.4的介质中发生突释,释放率可达86%,表现出良好的结肠定位释放行为.
The graft polymerization of sodium p-styrene sulfonate (SSS) was initiated on the surface of cross-linked polyvinyl alcohol (CPVA) microspheres by using cerium salt-hydroxy redox initiator system. The functional grafted microspheres CPVA- g-PSSS was used to investigate the performance, mechanism and release behavior of 5-aminosalicylic acid (5-ASA) .The results showed that under the conditions of strong electrostatic interaction, CPVA-g -PSSS showed a strong adsorption capacity for 5-ASA molecules with an adsorption capacity of 39.1 mg / g, which could effectively achieve drug loading.The release behavior of drug-loaded microspheres was strongly pH-dependent and at pH = 1 The medium did not release drug, but in the pH = 7.4 medium burst release, the release rate of up to 86%, showing good colon positioning release behavior.