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目的 探讨抗血小板聚集药物西洛他唑对老年脑梗死患者血小板膜糖蛋白变化的影响。方法 应用流式细胞术检测45例急性期老年脑梗死患者血小板活化分子标记物CD41、CD62P的含量水平,并对脑梗死组应用西洛他唑或阿司匹林治疗前后血小板活化分子表达的变化进行对比分析。结果 急性期脑梗死患者血小板膜糖蛋白CD41、CD62P的表达水平显著高于正常对照组(P<0.01);应用西洛他唑治疗后患者血小板膜糖蛋白表达明显下降,幅度高于应用阿司匹林治疗的患者。结论 老年脑梗死患者急性期血小板活化功能明显增强;西洛他唑能抑制血小板粘附分子的表达,对改善患者的预后有帮助。
Objective To investigate the effect of antiplatelet drug cilostazol on platelet membrane glycoprotein in elderly patients with cerebral infarction. Methods Flow cytometry was used to detect the levels of platelet-activating molecular markers CD41 and CD62P in 45 patients with acute cerebral infarction. The changes of platelet-activating molecules before and after treatment with cilostazol or aspirin were compared . Results The levels of platelet membrane glycoproteins CD41 and CD62P in patients with acute cerebral infarction were significantly higher than those in the normal control group (P <0.01). After treatment with cilostazol, the expression of platelet membrane glycoprotein was significantly lower than that with aspirin Of patients. Conclusion Platelet activation in acute cerebral infarction patients is obviously enhanced. Cilostazol can inhibit the expression of platelet adhesion molecules, which is helpful to improve the prognosis of patients.