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目的:探讨多西紫杉醇、奥沙利铂、5-氟尿嘧啶和亚叶酸钙联合化疗方案治疗进展期胃癌的疗效和不良反应。方法:26例进展期胃癌患者给予化疗方案为:多西紫杉醇80 mg/m2,奥沙利铂125 mg/m2,5-氟尿嘧啶500 mg/m2,亚叶酸钙200 mg/m2,每3周为1个周期,3个周期后按WHO标准评价近期疗效和不良反应,随访疾病进展时间和中位生存期。结果:完全缓解3例,部分缓解12例,疾病稳定8例,疾病进展3例,总有效率57.69%,中位疾病进展时间为5.2个月,中位生存期为9.8个月。不良反应:白细胞减少、恶心、呕吐、脱发、周围神经毒性。结论:多西紫杉醇联合化疗方案治疗进展期胃癌近期疗效好,不良反应可耐受。
Objective: To investigate the efficacy and adverse reactions of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin combined with chemotherapy in the treatment of advanced gastric cancer. Methods: Twenty-six patients with advanced gastric cancer received docetaxel 80 mg / m 2, oxaliplatin 125 mg / m 2, fluorouracil 500 mg / m 2 and leucovorin 200 mg / m 2 every 3 weeks 1 cycle, 3 cycles after the WHO evaluation of the recent efficacy and adverse reactions, follow-up disease progression time and median survival. Results: Completely relieved in 3 cases, partially relieved in 12 cases, stable in 8 cases, progressive in 3 cases, total effective rate was 57.69%. The median time to progression was 5.2 months and the median survival time was 9.8 months. Adverse reactions: leukopenia, nausea, vomiting, hair loss, peripheral neurotoxicity. Conclusion: Docetaxel combined with chemotherapy for advanced gastric cancer has good curative effect in the near future and adverse reactions can be tolerated.