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细胞外信号调节激酶(ERK)信号通路参与调控细胞增殖与分化,其在乙醛刺激的肝星状细胞(HSC)活化中的意义鲜见报道。我们观察了特异性阻断剂P1398059阻断ERK活性后对乙醛刺激的HSc增殖、Ⅰ型胶原分泌、转化生长因子β1 (TGFβ1)mRNA及Na+／Ca2+交换蛋白表达的影响,以探讨
The extracellular signal-regulated kinase (ERK) signaling pathway is involved in the regulation of cell proliferation and differentiation, and its significance in the activation of acetaldehyde-stimulated hepatic stellate cells (HSC) is seldom reported. We observed the effect of specific blocker P1398059 on ERK-induced HSc proliferation, type I collagen secretion, TGFβ1 mRNA and Na + / Ca2 + exchange protein after ERK activity was blocked