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作者指出,硫脲类抗甲状腺药的应用,几乎已近半个世纪,但在欧州仍把它作为对年轻 Graves病人起始治疗的首选药物。这类药物的主要作用为抑制碘有机化和碘酪氨酸偶联,导致甲状腺素合成减少。丙基硫氧嘧啶能抑制1型5′-脱碘酶,减少T_3生成,但其它硫脲类则否。硫脲类药物虽可控制各种病因引起的甲亢,但只有部分 Graves 病人能在停药后产生症状缓解。苏格兰某中心随访434名病人,显示在5年仍保持缓解者42%;10年仍保持缓解39%;此后则仅有微
The authors note that the use of thiourea-based antithyroid drugs has been nearly half a century old, but it is still the preferred drug in Europe for initial treatment of young Graves. The main effect of these drugs is to inhibit iodine organic and iodine tyrosine coupling, resulting in decreased thyroxin synthesis. Propylthiouracil inhibits type 1 5’-deiodinase and reduces T_3 production, but not other thioureas. Thiourea drugs can control various causes of hyperthyroidism, but only some of Graves patients can relieve symptoms after stopping. A total of 434 patients were followed up in a Scottish center, showing 42% of those who remained remitted at 5 years; 39% remained remitted in 10 years; thereafter only