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目的探讨结合珠蛋白(Hp)基因多态性与2型糖尿病(T2DM)患者糖尿病视网膜病变(DR)发病的关系。方法将317例T2DM患者分为糖尿病无视网膜病变(NDR)组和DR组,并选取100名正常人作为对照(NC)组。采用PCR技术扩增Hp1和Hp2特异的目的片段,分析Hp基因型及糖尿病(DM)病程、尿白蛋白(UAlb)等生化指标与DR的关系。结果 NDR组、DR组和NC组间Hp等位基因和基因型频率比较,均无统计学差异(P>0.05)。经Logistic回归分析显示,DM病程和24h UAlb是DR的独立危险因素,Hp可能与DR无相关性。结论 Hp基因多态性可能与DR无相关性,而DM病程和24hUAlb是DR的独立危险因素。
Objective To investigate the association of Hp gene polymorphism with diabetic retinopathy (T2DM) in patients with type 2 diabetes mellitus (DR). Methods 317 patients with T2DM were divided into diabetic retinopathy (NDR) group and DR group, and 100 normal subjects were selected as control group (NC). The specific fragments of Hp1 and Hp2 were amplified by polymerase chain reaction (PCR), and the relationship between Hp genotype, course of diabetes mellitus and urinary albumin (UAb) and DR was analyzed. Results There was no significant difference in Hp allele and genotype between NDR group, DR group and NC group (P> 0.05). Logistic regression analysis showed that the duration of DM and 24h UAlb were independent risk factors for DR, and Hp may not be related to DR. Conclusion There is no correlation between Hp gene polymorphism and DR, but DM duration and 24hUAlb are independent risk factors of DR.