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耳硬化症由于在不同种族和家族中发病率有差异并常发生在纯合子双胞胎中,因此多认为其发病与遗传有关。此外,在某些疾病中HLA-键基因影响病变的易感性或是病变的结果。作者系统地研究了68例希腊人耳硬化症的主要组织相容性复合体的产物,为HLA的第6号染色体,并用400例健康人作对照。病人的诊断根据手术和实验室检查证实。全部病人测定组织相容性抗原,用56份HLA抗血清分别测定13份HLA-A和14份HLA-B抗原的特异性。结果:耳硬化症病人中抗原All,Bl4和Bw35的出现率显著增
Due to differences in incidence among different races and families and often in homozygous twins, otosclerosis is thought to be more genetically related. In addition, in some diseases HLA-key genes affect the susceptibility of the lesion or the result of the lesion. The authors systematically studied the product of 68 major histocompatibility complexes of the Greek otosclerosis, chromosome 6 of HLA, and used 400 healthy controls. The patient’s diagnosis was confirmed by surgery and laboratory tests. All patients tested for histocompatibility antigens, and the specificity of 13 HLA-A and 14 HLA-B antigens was determined by using 56 parts of antiserum. Results: The occurrence of All, Bl4 and Bw35 in patients with otosclerosis was significantly increased