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为研究不同剂量大黄对附子的解毒作用以指导临床合理用药，将不同剂量的大黄与固定取量的附子分别组方，采用单煎与合煎提取工艺，应用紫外分光光度法测定其乌头碱的含量。结果：大黄配附子合煎组方乌头碱含量低于大黄配附子单煎组方。单煎与混煎组方中乌头碱的含量均随着大黄剂量的增加而减少，两者均呈线性相关。实验表明：在一定范围内，大黄对附子的解毒作用随着大黄剂量的递增而增加。
In order to study the detoxification effect of different doses of rhubarb on aconite to guide clinical rational use of drugs, different doses of rhubarb and fixed amount of aconite were divided into groups, using single-fried and co-fried extraction process, the application of UV spectrophotometry aconitine Content. Results: The content of aconitine in rhubarb and aconite combined decoction group was lower than that of rhubarb and aconite single decoction group. The content of aconitine in both single-decoction and decoction decoction decreased with the increase of rhubarb dosage, both showed a linear correlation. Experiments show that: in a certain range, rhubarb detoxification of aconite with the dose of rhubarb increases.