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目的观察拉贝洛尔对妊娠期高血压患者血压及妊娠结局的影响。方法随机选取医院2014年3月-2015年3月收治的妊娠期高血压患者200例,采用电脑随机分组法分为试验组与对照组,每组100例。对照组给予硫酸镁治疗,试验组在对照组治疗的基础上给予拉贝洛尔治疗。对比2组孕妇平均收缩压、舒张压、24 h蛋白尿及妊娠结局。结果治疗前2组患者收缩压、舒张压、24 h蛋白尿比较差异均无统计学意义(P>0.05),治疗后2组平均收缩压、舒张压、24 h蛋白尿均降低,且试验组低于对照组,差异均有统计学意义(P<0.05)。试验组不良妊娠结局发生率明显低于对照组,差异有统计学意义(P<0.05)。结论拉贝洛尔可降低妊娠期高血压患者的血压水平,改善患者妊娠结局,保证母婴平安。
Objective To observe the effect of labetalol on blood pressure and pregnancy outcome in patients with gestational hypertension. Methods 200 cases of hypertensive disorder complicating pregnancy were randomly selected in our hospital from March 2014 to March 2015. The patients were randomly divided into experimental group and control group with 100 cases in each group. The control group was given magnesium sulfate, and the experimental group was given labetalol on the basis of the control group. The mean systolic blood pressure, diastolic blood pressure, 24 h proteinuria and pregnancy outcome in two groups were compared. Results Before treatment, systolic blood pressure, diastolic blood pressure and 24 h proteinuria had no significant difference (P> 0.05). After treatment, mean systolic blood pressure, diastolic blood pressure and 24 h proteinuria decreased in both groups, and the experimental group Lower than the control group, the difference was statistically significant (P <0.05). The incidence of adverse pregnancy outcomes in the experimental group was significantly lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Labetalol can reduce the blood pressure in patients with gestational hypertension, improve pregnancy outcomes and ensure the safety of mother and baby.