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目的:探讨不同海拔的高血压患者血降钙素基因相关肽(calcitonin gene-related pep-tide,CGRP)、肾上腺髓质素(adrenomedulin,ADM)、髓过氧化物酶(myeloperox-idase,MPO)、脑钠肽(brain natriuretic peptide,BNP)浓度的变化,以期对高血压的诊断、治疗和预后判断提供理论依据。方法:采用放射免疫法测定血浆CGRP、ADM含量,用比色法测定血清MPO含量,用Triage荧光免疫分析仪测定BNP含量。结果:高海拔及西宁地区高血压组患者血CGRP含量分别低于同海拔正常对照组(均P<0.05);高海拔及西宁地区高血压患者血ADM、MPO、BNP含量分别高于同海拔正常对照组(均P<0.05);高原地区高血压组及正常组血CGRP含量分别低于西宁地区高血压组及正常组(均P<0.05);高原地区高血压组及正常组ADM、BNP含量分别高于西宁地区高血压组及正常组(均P<0.05);高原地区高血压组及正常组血清MPO含量分别与西宁地区高血压组及正常组比较均无显著性差异(均P>0.05)。结论:高海拔地区人群CGRP含量降低,ADM、MPO及BNP升高,这种趋势在高血压患者中更为明显,提示:海拔高度影响高原居住人群的血管活性物质分泌,可能是高原不适应,导致血压升高的因素之一。
Objective: To investigate the effects of calcitonin gene-related pep-tide (CGRP), adrenomedulin (ADM), myeloperox-idase (MPO) , Brain natriuretic peptide (BNP) levels in order to provide a theoretical basis for the diagnosis, treatment and prognosis of hypertension. Methods: Plasma CGRP and ADM levels were measured by radioimmunoassay. MPO levels were determined by colorimetry and BNP levels by Triage fluorescence immunoassay. Results: The blood levels of CGRP in high altitude and Xining hypertensive patients were lower than those in normal altitude group (all P <0.05). The levels of blood ADM, MPO and BNP in high altitude and Xining areas were higher than those in normal elevation (P <0.05). The levels of plasma CGRP in hypertension group and normal group were lower than those in Xining normal group and normal group respectively (all P <0.05). The contents of ADM and BNP in high blood pressure group and normal group (P <0.05). There was no significant difference in serum MPO levels between hypertension group and normal group (P> 0.05) in Xining area and normal group ). CONCLUSION: CGRP, ADM, MPO and BNP are elevated in high altitude area. This tendency is more obvious in patients with hypertension, suggesting that the elevation of altitude may affect the excretion of vasoactive substances in the resident population, which may be caused by plateau incompetence, One of the factors that causes high blood pressure.