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自1971年首次报道抗结核药可增加口服甾体避孕药的突破性出血发生率之后,陆续发现抗惊厥药、抗菌素和一些具有酶诱导活性的药物均使妊娠和突破性出血的发生率增高。
Since the first report of anti-TB drugs in 1971 to increase the incidence of breakthrough bleeding of oral steroid contraceptives, one after another found that anticonvulsants, antibiotics and some drugs with enzyme-induced activity increased the incidence of pregnancy and breakthrough bleeding.