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[目的]研究中药醒脑静注射液对沙土鼠急性脑缺血再灌注损伤的作用。[方法]采用沙土鼠双侧颈总动脉夹闭制作沙土鼠急性全脑缺血模型,观察干预性腹腔注射西药尼莫地平和中药醒脑静注射液对缺血再灌注急性期沙土鼠脑组织中MDA含量和SOD活力的影响。[结果]西药尼莫地平和醒脑静注射液均能显著提高脑缺血再灌注后SOD活力和降低MDA含量,醒脑静注射液疗效和西药尼莫地平无显著差异,而醒脑静大中小剂量组之间有较显著的差异,疗效随剂量的增加而增大。[结论]醒脑静注射液作为抗自由基损伤的中药和西药尼莫地平有相当的疗效。
[Objective] To study the effect of Xingnaojing injection on acute cerebral ischemia-reperfusion injury in gerbils. [Methods] A model of acute global cerebral ischemia in gerbils was established by clamping the common carotid artery of gerbils. The interventional intraperitoneal injection of Nimodipine and Xingnaojing injection was used to observe the cerebral tissue of gerbils during the acute phase of ischemia-reperfusion. The effect of MDA content and SOD activity. [Results] Western medicine nimodipine and Xingnaojing injection can significantly increase the activity of SOD and decrease the content of MDA after cerebral ischemia-reperfusion. There is no significant difference between the efficacy of Xingnaojing injection and western medicine Nimodipine. There was a significant difference between the low and medium dose groups, and the efficacy increased with increasing dose. [Conclusion] Xingnaojing injection has a good effect as a medicine against free radical damage and western medicine nimodipine.