给大白鼠以玉米为主的偏食饲料,同时经饮水投予氟化钠200ppm,为期两个月,造成典型的骨软化性氟骨症模型。饲料中补充适量钙盐(1000ppm碳酸钙)可消除偏食本身的影响。这种氟骨症模型复制方法简便,实验周期短,形态指标明确,有利于筛选有效防治药物及对氟骨症发生机理与影响因素的研究。 To the rats with corn-based partial eclipse feed, while drinking water to sodium fluoride 200ppm, for two months, resulting in a typical model of osteomalacia osteofluorosis. Feeding the right amount of calcium salt (1000ppm calcium carbonate) can eliminate the impact of the partial eclipse itself. This method of skeletal fluorosis has the advantages of simple method, short experimental period and definite morphological index, which is good for screening effective prevention and treatment of the disease and studying the mechanism and influencing factors of skeletal fluorosis.