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目的 观察长效托宁与阿托品治疗急性有机磷农药中毒 (AOPP)的效果。方法 以长效托宁配合氯解磷定治疗 5 7例AOPP患者 ,并与阿托品配合氯解磷定治疗 2 2例AOPP患者进行比较。结果 长效托宁可使轻、中、重度AOPP患者中毒症状持续的时间缩短 ,M样症状时间分别为0 .2、0 .5、0 .6h ,对照组分别为 1.2、2 .3、3.7h ;中枢神经系统症状时间分别为 0 .7、4.7、12 .2h ,对照组分别为 13.8、17.3、19.3h ;用药量减少 ,分别为 2 .3、7.2、10 .2mg ,对照组分别为 11.0、2 6 .8、5 4.3mg ;治愈时间也缩短 ,分别为 1.1、1.9、2 .7d ,对照组分别为 1.8、2 .8、3.5d。两组比较 ,差异均有非常显著性(P <0 .0 1)。结论 长效托宁是一种比阿托品治疗效果好、不良反应少的抗胆碱能新药。
Objective To observe the effects of long-acting topin and atropine in the treatment of acute organophosphorus pesticide poisoning (AOPP). Methods Fifty-seven patients with AOPP were treated with long-acting tonoplatin and chlorpheniramine, and compared with 22 patients with AOPP treated with atropine and chlorpromazine. The results of long-term effects of Toxe can light, moderate and severe AOPP patients with symptoms of poisoning continued shortening time, M-like symptoms were 0.2,0.5,0.6 h, respectively, the control group were 1.2,2.3,3.7 h ; Central nervous system symptoms were 0. 7,4.7,12 .2 h, respectively, the control group were 13.8,17.3,19.3 h; medication decreased, respectively, 2.3, 7.2, 10.2 mg, the control group were 11.0 , 2 6 .8,5 4.3mg; cure time also shortened, respectively 1.1,1.9,2 .7 d, the control group were 1.8,2 .8,3.5 d. The differences between the two groups were significant (P <0.01). Conclusion Long-acting tonnage is a kind of new anticholinergic agent with better therapeutic effect and less adverse reactions than atropine.