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目的:探讨苍术炮制前后水提物药效变化,从药效变化的角度探讨苍术的炮制机制。方法:以湿阻中焦证大鼠为模型,测定不同组别大鼠小肠推进率、血清胃泌素水平、尿量、尿液AQP2含量。结果:各给药组大鼠小肠推进率、血清胃泌素水平增强,麸品较阴性组有显著差异;生品高剂量组能增加模型大鼠尿量、降低尿液AQP2含量,较阴性组有差异。结论:麸品水提物明显增强模型大鼠小肠推进率、提高血清胃泌素水平,提示苍术麸炒以后能增强健脾和胃作用;药物对模型大鼠尿量及尿液AQP2含量的影响,提示苍术麸炒后燥性得以缓和。
OBJECTIVE: To investigate the pharmacodynamic changes of aqueous extracts before and after the herb was processed, and to explore the processing mechanism of the herb from the perspective of the change of pharmacodynamics. Methods: The rat model of small intestine was used to determine the intestinal propulsion rate, serum gastrin level, urine output and urinary AQP2 content in different groups of rats. Results: The small intestine propulsion rate, serum gastrin level increased and the bran product had significant difference compared with the negative group. The high dose group of raw product increased the amount of urine and decreased the content of AQP2 in urine in the model group Differences. CONCLUSION: Water extract of bran product can significantly promote small intestine propulsion rate and increase serum gastrin level in model rats, suggesting that herb extract may enhance spleen and stomach after excretion of Rhizoma in Rhizoma. The effects of drugs on urine volume and urine AQP2 content in model rats , Suggesting that after drying Atractylodes bran can be alleviated.